Skeeter Syndrome Treatment

As with most allergies, Skeeter Syndrome treatment deals primarily with prevention, and symptom management. That is, treating the individual symptoms as they appear or attempting to preempt them with the help of medications. It’s a good idea to have a medical kit at home to help manage symptoms that might appear.

This includes oral antihistamines, anti-itch creams,  anti-inflammatory and pain medication.  Treatment usually involves treating swelling, itching, and discomfort both topically and internally.

Important: Individuals who have suffered a serious allergic reaction, such as anaphylaxis, to other insect bites should have an  epinephrine autoinjector (EpiPen) on hand at all times as anaphylaxis can occur with mosquito allergies.

The itching associated with a  regular mosquito bite tends to be magnified a lot with skeeter syndrome. Added to the swelling, blistering and possibility of infection it can be the most torturous symptom. Alleviating the symptoms is key to avoiding the bite becoming infected or developing into blisters or a raw sore. 

Thankfully, there are many medications, both natural and secular to help alleviate this uncomfortable sensation.

Skeeter Syndrome Treatment – Anti-Itch Treatments

Topical Benadryl

Skeeter Syndrome Treatment - Benadryl Topical Itch Stopping Cream, Extra Strength, 1-Ounce Tubes (Pack of 4) Topical Benadryl is an important item and should be kept on hand at all times. There are different strengths, but the extra strength is the best choice due to the severity of the symptoms. The ointment is applied directly to the affected area as often as needed.

Calamine Lotion

Skeeter Syndrome Treatment - Caladryl Lotion, Calamine Plus Itch Reliever, 6-Ounce Bottle Calamine lotion is one of the most effective topical solutions to relieve itching. It contains a mixture of Zinc Oxide and Ferric Oxide, and is commonly used to treat poison oak, poison ivy and poison sumac. It also helps dry weeping or oozing caused by irritation.


Calamine lotion is for external use only, and you should avoid getting it in your eyes, nose, mouth or genital/anal areas. There are no known drug interactions, but be sure to let your pharmacist know if you have other drug allergies or are on other medications.

Baking soda

Skeeter Syndrome Treatment - ARM & HAMMER Baking Soda - 13.5 lb. bag

Baking soda is a natural option for topical treatment of itching and discomfort. Mix a little water with baking soda and apply the paste to the affected area to relieve itching.

Add baking soda to a hot bath, and take a long soak. It will help with swelling, redness and itching as well as help you avoid infections.

Apple Cider Vinegar

Skeeter Syndrome Treatment - Bragg Apple Cider Vinegar Organic Raw -- 32 fl oz


Apple cider vinegar also has natural anti-itch benefits. Wet a cotton ball with vinegar and use a band aid or medical tape to apply it to the affected area for extended relief.

Hydrocortisone Cream

Skeeter Syndrome Treatment - Cortizone-10 Max Strength Cortizone-10 Crme, 2oz Boxes (Pack of 2)  Hydrocortisone cream is a topical treatment that is commonly used to treat eczema. It helps with swelling, redness, itching and discomfort.  It works wonders for extremely inflamed bites, and as a preemptive treatment.


In many cases bites don’t turn into welts for a few days, so treating the bite before it swells is a good idea to avoid and minimize discomfort.

Hydrocortisone is a topical steroid, so be sure to consult your physician if you are on prescription medication or suffer from a medical condition.

 Skeeter Syndrome Treatments for Inflammation


Skeeter syndrome Treatment - Genuine Bayer Aspirin 325mg Tablets 200 Coated Tablets


A well-kept secret is that aspirin works well as a topical pain reliever & anti-inflammatory. Crush a few pills and add a few drops of water. Apply the paste to the affected area, leave it on overnight for maximum effect. 


Benadryl or Sudafed

Skeeter Syndrome treatment - Benadryl® Allergy Ultratabs - 148 tabletsBenadryl, Sudafed any other oral antihistamines can help you treat & manage Skeeter Syndrome Symptoms. Take a dose at can  help treat swelling, and relieve itching for hours.

This is especially useful important if you have a bite in an awkward place, such as your but or toes,  and can help you avoid embarrassing situations.



Meat Tenderizer

Skeeter Syndrome Treatment - Badia, Meat Tenderizer, 4.5-OunceYes, believe it or not meat tenderizer that contains papain is helpful in treating Skeeter Syndrome. Papain is an enzyme that helps breaks down the proteins found in the mosquito saliva. This can be especially helpful in relieving skeeter syndrome symptoms, and preempting a serious outbreak.



9 thoughts on “Skeeter Syndrome Treatment

  1. Ella Crutz

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  2. Pingback: FAQ about Skeeter Syndrome & Mosquito Bite Allergies - Skeeter Syndrome

  3. Vera

    Meat tenderizer is THE BEST for itch relief, and it works FAST (takes only a few seconds to feel the difference!). The easiest way to do it: take a small amount of powder, add a few drops of water to make a paste, spread on itchy spots.

    Our regimen: when itching begins, apply meat tenderizer for a few minutes, wipe off, then apply Hydrocortisone cream (this combination provides about 6 hours of itch relief). Plus, give a dose of Benadryl every 6 hours.

  4. Charlotte Shirvington

    I have started to have severe reactions to mosquito bites the past 3 years. It all started after I was bitten by a horsefly. Before then, I had little to no reaction to the things. Now, I get a red lump, the tlast time (2 months ago) I had a yellow patch in the middle of all the read. The next day it started to blister up, and it was the worst blister I have had. The redness spread out in a huge circle on my leg, and at the biggest it almost touched from one side of my leg round to the other. It was so painful. I had to get to the emergency room asap for them to look at it and give me some hardcore antibiotics. That sucked so bad. I only had one bad bite last year and the year before, so I don’t know what I’m doing to make me react once? No idea. I’m hoping for no more this year. Funny thing is, it’s only when they bite the fleshy part of ym lower leg. I got 2 mossy bites on my inner thigh, above the knee- no reaction. I got a bite the other day just below my ankle- no reaction. It is insane why it reacts there.

  5. Chasity Carpenter

    My 12 yr old son has 6 huge circles on his legs and 1 on his arm it was Skeeter bites but it had swelled made blisters which popped so it was all raw skin. The doctor said ringworm at first but then said Skeeter bites , we knew he was allergic but it never did this. It’s been bout a month the places is healing but really dry is there anything to help that?

  6. carole heath

    I was badly.bitten by mosquitos in the summer of 2018. I had an allergic reaction pain red inflamed bites. My leg became very swollen. I was given antihistamine tablets and antibiotic cream to apply to the area. The marks etc eventually went after about 4 or 5’weeks. In the October I started to feel unwell dizzy 😵 and light headed. I then got what I thought where panic attacks I felt breathless and had shivers. That went off after awhile but in the december I got a bad virus and I went to my gp twice complaining of tiredness etc. She said i most likely had post viral fatigue. And did some blood tests it came back low vitamin d levels. Which i now take a supplement for daily. And I had also been suffering with skeeter syndrome brought on by the mosquito bites which had caused an allergic reaction and my system had been low that us most likely why u had caught the viral infection too. All these months later I still feel very tired at times and light headed. My go said it could go on for another 6 months until I am completely better. I take everyday as it comes now and pace myself. I was a great walker everyday for 2 hours with my dog. But my walks are cut back as I come back exhausted if I do to much in one go. I am nearly 72. My gp said it will take longer because I am over 65. I hope I never get skeeter syndrome again it has really impacted on my life. But I must be positive and try to get better but in my own time.

  7. nancy rosemary forbes

    Hi Carole I hope you get back on track soon. I had skeeter syndrome a few years ago and a viral infection afterwards it was awlful for me too. It took me 9 months to fully recover not being negative. You must do things in your own time don’t let other people push you into things you aren’t ready for it just stresses you out more. I am ok now myself but as you say you wouldn’t want all that again and neither would I.
    Take care 😊 x

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